Addison's disease and diffuse cerebral sclerosis.

The rare combination of Addison's disease and diffuse cerebral sclerosis is now recognized to be something more than coincidence. Although only a small number of cases have been reported up to date, those cases have all followed a very similar pattern. This paper presents the case of a patient who is still alive and in whom, therefore, the diagnosis of diffuse cerebral sclerosis has not been confirmed histologically. The diagnosis of Addison's disease, however, has been confirmed beyond all doubt, and there is a positive family history for diffuse cerebral sclerosis.